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KMID : 1189220100370020135
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Korean Journal of Reproductive Medicine
2010 Volume.37 No. 2 p.135 ~ p.142
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Effectiveness of Soft Stimulation Protocol, Compared with Conventional GnRH Antagonist Multiple dose Protocol in Patients Undergoing Controlled Ovarian Stimulation with Intrauterine Insemination
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Kim Chung-Hoon
Kang Hyuk-Jae
Kim So-Ra
Jeon Gyun-Ho
Lee Hyang-Ah
Kim Sung-Hoon
Chae Hee-Dong
Kang Byung-Moon
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Abstract
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Objective: To evaluate the effectiveness of soft stimulation protocol using GnRH antagonist/clomiphene citrate (CC)/recombinant FSH (rFSH) in patients undergoing controlled ovarian stimulation (COS) with intrauterine insemination (IUI), compared with GnRH antagonist multiple dose protocol (MDP) using GnRH antagonist/rFSH.
Methods: Eighty infertile women were randomized to soft stimulation protocol group (n=40) or GnRH antagonist MDP group (n=40). In both groups, IUI was performed 36~40 hours after hCG injection. Statistical analysis was performed using Student’s t-test, χ2 test or Fisher’s exact test as appropriate.
Results: Total dose and days of rFSH required for COS were significantly fewer in soft stimulation protocol group (p<0.001, p<0.001). A premature LH surge did not occur in any patients of both groups. Clinical pregnancy rate per cycle was similar between the two groups.
Conclusion: Soft stimulation protocol provides comparable pregnancy rates to GnRH antagonist MDP despite fewer total dose and days of rFSH, and so can become one of the patient-friendly, cost-effective alternatives for infertile patients undergoing COS with IUI.
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KEYWORD
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GnRH antagonist, Soft stimulation protocol, Controlled ovarian stimulation, Intrauterine insemination
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